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Freed et al randomly assigned 40 patients who were 34 to 75 years of age and had severe Parkinson’s disease (mean duration 14 years) to receive a transplant of nerve cells (embryonic- from foetuses) or to undergo sham surgery, all were to be followed in a double blind manner for one year.
Aim: to investigate the effect of Dopamine (embryonic) on parkinson’s disease
independent variable: embryonic neurone transplant
dependent variable: subjective global ratings of change in symtoms of Parkinson’s
- cultured mesencephalic tissue from 4 embryos was implanted into the putamen bilaterally
- in the sham surgery- holes were drilled into the skull but the dura was not penetrated
- subjective global rating: on a scale of -3.0 to 3.0
negative score means worsening of symptoms
positive score means improvement in symptoms
Results: Human embryonic Dopamine neurone transplants survive only in patients with severe Parkinson’s disease, and in younger patients rather than older ones.
Conclusion: Dopamine is indeed linked to Parkinson’s and hence confirms the role of Dopamine in physical motivation and movements.
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